Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study

Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In AOC, extent of tumor resection (residual volume) most important prognostic factor for overall survival (OS) and progression-free (PFS). Neoadjuvant chemotherapy (NACT) interval (IDS) an experimental treatment introduced clinical practice order to improve cytoreduction rate prolong survival. aim this study was compare NACT+IDS PDS patients with AOC. Methods. This retrospective cohort included separated into two groups. first group treated had 59 patients, while second group, NACT + IDS, 33 patients. Results. A lower suboptimal (39.39%) found IDS than (57.63%). percentage complete higher (51.52%) those (38.98%). Nevertheless, median OS PFS were not significantly different between groups (p < 0.05). 35 months 31 groups, respectively. 16 19 group. Conclusion. Despite optimal after NACT+ method better PDS. decision either or should be tailored individual patient.